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Amiselimod hydrochloride
CAS No. 942398-84-7
Amiselimod hydrochloride( MT-1303 hydrochloride )
Catalog No. M16743 CAS No. 942398-84-7
A novel prodrug S1P receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | Get Quote |
|
| 5MG | 80 | Get Quote |
|
| 10MG | 120 | Get Quote |
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| 25MG | 203 | Get Quote |
|
| 50MG | 357 | Get Quote |
|
| 100MG | 537 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAmiselimod hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA novel prodrug S1P receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators.
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DescriptionA novel prodrug S1P receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators; the selectivity of the active metabolite amiselimod phosphate (Amiselimod-P) shows potent selectivity for S1P1 and high selectivity for S1P5 receptors, with minimal agonist activity for S1P4 and no distinct agonist activity for S1P2 or S1P3 receptors and approximately five-fold weaker GIRK activation than fingolimod-P; exhibits potent therapeutic efficacy with minimal cardiac effects.Multiple Sclerosis Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsMT-1303 hydrochloride
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PathwayGPCR/G Protein
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TargetLysophospholipid Receptor
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RecptorLysophospholipid Receptor
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Research AreaInflammation/Immunology
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IndicationMultiple Sclerosis
Chemical Information
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CAS Number942398-84-7
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Formula Weight413.9026
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Molecular FormulaC19H31ClF3NO3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESCCCCCCCOC1=C(C=C(C=C1)CCC(CO)(CO)N)C(F)(F)F.Cl
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Chemical Name1,3-Propanediol, 2-amino-2-[2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sugahara K, et al. Br J Pharmacol. 2017 Jan;174(1):15-27.
2. Kappos L, et al. Lancet Neurol. 2016 Oct;15(11):1148-59.
3. Harada T, et al. Br J Clin Pharmacol. 2017 May;83(5):1011-1027.
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